That’s why today we’re announcing two new steps to advance defensive acceleration in biology:

The steps we're taking today are part of a broader strategy to ensure advanced AI meaningfully advantages those working to prevent, detect, and respond to biological threats. That strategy includes equipping defenders through trusted access to advanced AI tools, accelerating the development of medical countermeasures, building earlier warning systems, strengthening diagnostics, preparedness, and response capabilities, and supporting a robust evaluations ecosystem. We will continue to share more about our work across these areas in the coming weeks.

As AI models become more capable in biology, we have been working to ensure those capabilities are deployed in ways that advance science while strengthening safeguards. Our approach has focused on building layered resilience: investing in preparedness evaluations, bio-specific capability assessments, safer model behavior for dual-use biological requests, monitoring and enforcement, expert red teaming, and security controls for higher-risk capabilities.

In July 2025, we released ChatGPT agent, the first model we treated as High Capability in biology under our Preparedness Framework and activated robust safeguards to minimize the risk of harm. Since then, we have continued refining those safeguards and sharing detailed assessments⁠(opens in a new window) as capabilities have continued to advance. We have also continued working closely with external testing groups on pre-deployment evaluations, whose findings help validate and inform our approach.